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Matrix metalloproteinases (MMPs), belonging to the metzincins superfamily, are a class of zinc-dependent endopeptidases that degrade various protein components of the ECM. Matrix metalloproteinases are produced by a variety of tissues and cells. MMPs are secreted by proinflammatory cells and uteroplacental cells, including fibroblasts, osteoblasts, endothelial cells, vascular smooth muscle, macrophages, neutrophils, lymphocytes, and cytotrophoblasts.