Unlock Exclusive Discounts & Flash Sales! Click Here to Join the Deals on Every Wednesday!
Official Full Name: myeloid cell nuclear differentiation antigen
Also known as: PYHIN3
Myeloid nuclear differentiation antigen (MNDA) is only detected in the nucleus of cells of the granulocyte-monocyte lineage. The 200-amino acid region of human MNDA is strikingly similar to protein regions encoded by a family of interferon-induced mouse genes named Ifi-201, Ifi-202, and Ifi-203 that are not regulated in a cell- or tissue-specific manner . The 1.8 kb MNDA mRNA, which contains an interferon-stimulated response element in the 5' untranslated region, is significantly upregulated in human monocytes exposed to interferon-α MNDA is located within 2,200 kb of FCER1A, APCS, CRP and SPTA1. MNDA is similar to IFI16 in its expression and/or regulation pattern, suggesting that these genes are involved in blood cell-specific responses to interferons.