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Also known as: MYH<br />This gene encodes a DNA glycosylase involved in DNA oxidative damage repair. At sites where adenine is inappropriately paired with guanine, cytosine, or 8-oxo-7,8-dihydroguanine (a major oxidative damage to DNA damage). This enzyme excises the adenine base from the DNA backbone. This protein is localized to the nucleus and mitochondria. This gene product is thought to function as an apoptotic signal in the introduction of single-strand breaks following oxidative damage. Mutations in this gene lead to a genetic predisposition to colorectal cancer known as mutyh-associated polyposis (MAP). Multiple transcript variants encoding different isoforms have been found for this gene.