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Official Full Name: nitric oxide synthase 1 adaptor protein
Also known as: CAPON; NPHS22; 6330408P19Rik
The gene encodes a cytosolic protein that binds to the signaling molecule neuronal nitric oxide synthase (nNOS). The protein has a C-terminal PDZ-binding domain that mediates interactions with nNOS, and an N-terminal phosphotyrosine-binding domain (PTB) that binds to the small monomeric G protein Dexras1. Studies of the associated protein in mice and rats revealed that the protein acts as an adapter protein that connects nNOS to specific targets such as Dexras1 and synapses. Alternative splicing results in multiple transcript variants encoding different isoforms.