Analysis of OX40/TNFRSF4 (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0474-LGZ)

Introduction

OX40 (CD134, TNFRSF4) was originally defined as a marker of T cell activation, and later discovered to be a member of the NGFR/TNFR superfamily with co-activation function. The OX40 gene is located on human chromosome 1 (mouse chromosome 4), encoding a 50kD type I transmembrane glycoprotein. The extracellular region has 191 amino acids and contains three complete and one shorter cysteine-rich domains (CRDs). Mainly expressed on activated effector T cells (Teffs) and regulatory T cells (Tregs), but also on NKT cells, NK cells and neutrophils.