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Official Full Name: poly(ADP-ribose) polymerase 1
Also known as: PARP; PARS; PPOL; ADPRT; ARTD1; ADPRT1; PARP-1; ADPRT 1; pADPRT-1; Poly-PARP
This gene encodes the chromatin-associated enzyme poly(ADP-ribosyl)transferase, which modifies various nucleoproteins with poly(ADP-ribosyl). This modification is DNA-dependent and involved in the regulation of various important cellular processes such as differentiation, proliferation, and tumor transformation, as well as molecular events that regulate cellular recovery from DNA damage. In addition, this enzyme may be the mutation site of Fanconi anemia and may be involved in the pathophysiology of type 1 diabetes.