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Periostin (POSTN, PN or OSF-2) is an extracellular matrix secreted protein. Human Periostin protein contains 836 amino acids, molecular weight is about 93.3kDa, about 36kbp, located on chromosome 13q13.3. The human Periostin protein structure contains an amino-terminal secretory signal peptide, a cysteine-rich amino-terminus, four homologous repeat regions and a hydrophilic carboxyl-terminus.