Analysis of Pik3r1 Gene Rearrangement by Southern Blot Technology (CAT#: STEM-MHT-0041-LGZ)

Introduction

Official Full Name: phosphoinositide-3-kinase regulatory subunit 1
Also known as: PI3K; p50alpha; p55alpha; p85alpha
Insulin receptor substrate binding activity; phosphatidylinositol 3-kinase regulatory subunit binding activity; and protein heterodimerization activity. Involved in multiple processes, including negative regulation of stress fiber assembly; positive regulation of cellular component organization; positive regulation of protein import into the nucleus. Acts upstream or within several processes, including apoptotic signaling; negative regulation of osteoclast differentiation; positive regulation of tumor necrosis factor production. Located in several cellular components, including cell-cell junctions; the cis-Golgi network; and the perinuclear endoplasmic reticulum membrane. Some contain protein complexes. Expressed in several structures, including the digestive system; brain; eyes; genitourinary system; and integrative system. For the study of X-linked aglobulinemia. The human homologue of this gene has been associated with several diseases, including SHORT syndrome; astroblastoma; endometrial cancer (multiple); immunodeficiency; and type 2 diabetes. Homologous to human PIK3R1 (phosphoinosine-3-kinase regulatory subunit 1).