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Also known as: PK1; PKL; RPK; PKRL
The protein encoded by this gene is a pyruvate kinase that catalyzes the transphosphorylation of phosphoenolpyruvate to pyruvate and ATP, the rate-limiting step of glycolysis. Defects in this enzyme, due to gene mutations or genetic variations, are a common cause of chronic hereditary nonspherical hemolytic anemia (CNSHA or HNSHA). Multiple transcript variants encoding different isoforms have been found for this gene.