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Islet PP cells secrete pancreatic polypeptide (PP). PP was first discovered in chickens in 1968, and the entire family of structurally related peptides has been referred to as the pancreatic polypeptide family since then. However, in 1993, Larhammar et al. found that NPY was older in evolution and contributed more to evolution. Therefore, it is more appropriate to rename the pancreatic polypeptide family as NPY family. Like NPY, PP is also a polypeptide consisting of 36 amino acids with a molecular weight of 4179. Inhibit the secretion of insulin through paracrine and autocrine, and at the same time inhibit the secretion of pancreatic juice, especially inhibit the secretion of bicarbonate and trypsin, weaken the contraction of the gallbladder, strengthen the tension of the common bile duct, and inhibit the movement of the gastric antrum and small intestine. The release of PP is mainly inhibited by growth hormone, gastric inhibitory peptide and vasoactive intestinal peptide. PP not only has an effect on the exocrine of the pancreas, but also has an effect on the endocrine of the pancreas.