Analysis of RGS4 Gene (Mutation) by RT-qPCR (CAT#: STEM-MT-0624-LGZ)

Introduction

Official Full Name: regulator of G protein signaling 4<br />Also known as: RGP4; SCZD9<br />Members of the regulator of G protein signaling (RGS) family are GTPase-activating protein (gap) regulatory molecules of the G α subunit of heterotrimeric G proteins. RGS proteins are capable of inactivating G protein subunits of the Gi α, Go α, and Gq α subtypes. They convert the G protein to the inactive GDP-bound form. Regulators of G protein signaling 4 belong to this family. All RGS proteins share a conserved 120 amino acid sequence known as the RGS domain. Regulator of G protein signaling 4 protein shares 37% identity with RGS1 and 97% identity with rat Rgs4. This protein negatively regulates signaling upstream or at the level of heterotrimeric G proteins and localizes in the cytoplasm. Alternative splicing transcript variants of this gene have been identified.