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The proto-oncogene c-KIT is the gene encoding a receptor tyrosine kinase protein known as protein tyrosine kinase KIT, CD117 (cluster of differentiation 117), or mast/stem cell growth factor receptor (SCFR). Multiple transcript variants of this gene have been found, encoding different isoforms. KIT is a cytokine receptor expressed on the surface of hematopoietic stem cells as well as other cell types.