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Official Full Name: SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily e, member 1
Also known as: CSS5; BAF57
The protein encoded by this gene is part of the ATP-dependent large chromatin remodeling complex SWI/SNF, which is required for the transcriptional activation of genes normally repressed by chromatin. Encoded proteins, either alone or in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA entering or exiting nucleosomes. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome displacement activities of the SWI/SNF complex. Unlike most SWI/SNF complex proteins, this protein has no yeast counterpart.