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Official Full Name: transaldolase 1
Also known as: TAL; TALH; TAL-H; TALDOR
Transaldolase 1 is a key enzyme in the pentose phosphate nonoxidative pathway, providing ribose 5-phosphate for nucleic acid synthesis and NADPH for lipid biosynthesis. This pathway also maintains the reduced state of glutathione, which protects thiols and cellular integrity from oxygen free radicals. The functional gene of transaldolase 1 is located on chromosome 11, and the pseudogene is located on chromosome 1, but there are conflicts in the map positions. The second and third exons of the gene develop through the insertion of a retrotransposable element. This gene is thought to be involved in multiple sclerosis.