Analysis of Tie1/TIE/JTK14 by ELISA (CAT#: STEM-MB-1577-LGZ)

Introduction

Tyrosine protein kinase receptor Tie1 is a single transmembrane type I membrane protein, belonging to the protein kinase superfamily, tyrosine protein kinase family and Tie subfamily. Tie1 has three EGF-like domains, three fibronectin type III domains, two immunoglobulin like C2-type domains, and one protein kinase domain. Tie1 is a cell surface protein specifically expressed in endothelial cells; however, studies have shown that it can also be expressed in immature hematopoietic cells and platelets. Tie1 is essential for the survival and growth of microvascular endothelial cells during the capillary emergence phase of vascular development. Tie1 up-regulates the cell adhesion molecules VCAM-1, E-selectin, and ICAM-1 through a p38-dependent mechanism. The expression of Tie1 enhances the adhesion of monocyte derived immune cells to endothelial cells. Tie1 has a pro-inflammatory effect and plays an important role in inflammatory diseases of the endothelium such as atherosclerosis.