Analysis of VISTA/B7-H5 (Human) by MSD Hypersensitive Multi-Factor Electrochemiluminescence Analyzer (CAT#: STEM-MB-0630-LGZ)

Introduction

V-domain Ig suppressor of T cell activation (VISTA) belongs to the B7 family of molecules and shows significant homology with PD-L1 and PD-L2. Unlike other immune checkpoint molecules, VISTA is constitutively expressed on naive T cells and is lost during an immune response; in addition to T cells, VISTA is also expressed on the surface of antigen-presenting cells. VISTA inhibits T-cell activation through T-intracellular and T-extracellular mechanisms.