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Official Full Name: WD repeat domain 33<br />Also known as: NET14; WDC146<br />This gene encodes a member of the WD repeat protein family. The WD repeat is a minimally conserved region of approximately 40 amino acids, usually surrounded by gly-his and trp-asp (GH-WD), that may facilitate heterotrimeric or multiprotein complex formation. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. The gene is highly expressed in the testis, and the protein localizes to the nucleus. This gene may play an important role in cell differentiation and/or DNA recombination mechanisms. Multiple alternatively spliced transcript variants encoding different isoforms of this gene have been found.