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Official Full Name: YOD1 deubiquitinase
Also known as: DUBA8; OTUD2; PRO0907
Protein ubiquitination controls many intracellular processes, including cell cycle progression, transcriptional activation and signal transduction. This dynamic process involves ubiquitin-conjugating enzymes and deubiquitinating enzymes, which add and remove ubiquitin. Deubiquitinases are cysteine proteases that specifically cleave ubiquitin from ubiquitin-binding protein substrates. The protein encoded by this gene belongs to the DUB subfamily, characterized by the Ovarian Tumor (OTU) domain. Alternative splicing results in multiple transcript variants.