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Apolipoprotein A-I (apo A-I) an indispensable component and a major structural protein of high-density lipoprotein (HDL), plays a vital role in reverse cholesterol transport and cellular cholesterol homeostasis since its identification.<br /><br />High-density lipoproteins (HDL) are circulating particles composed of phospholipids, cholesterol, and proteins. There is a well established inverse correlation between plasma levels of HDL-associated cholesterol (HDL-C) and the incidence of cardiovascular disease. The partitioning of apolipoprotein A-I (apoA-I) molecules in plasma between HDL-bound and -unbound states is an integral part of HDL metabolism.