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Apolipoprotein A [apo(a)] is a protein carried in HDL ("good") cholesterol. It helps start the process for HDL to remove bad types of cholesterol from your body. In this way, apolipoprotein A can help to lower your risk for cardiovascular disease.<br /><br />Plasminogen is a secreted protein that upon cleavage by urokinase plasminogen activator (uPA) or tissue plasminogen activator (tPA) is converted to plasmin, a broad range protease capable of cleaving fibrin and other ECM components. Plasminogen is secreted by the liver as a single-chain 92-kDa glycoprotein with glutamine as the N-terminal amino acid (Glu-plasminogen). It is composed of five kringle-like domains containing “lysine-binding sites” and a C-terminal domain homologous to other trypsin-like proteases.