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MHC class I molecules are found on the surface of all nucleated cells in the body. These molecules present peptides from within the cell to the immune system, and play an important role in alerting the immune system about cells infected by viruses. MHC class I molecules (MHC-I) are cell surface recognition elements expressed on virtually all somatic cells. These molecules sample peptides generated within the cell and signal the cell's physiological state to effector cells of the immune system, both T lymphocytes and natural killer (NK) cells.