BIOshell™ columns provide maximum speed and efficiency for the separation of biomolecules on UHPLC and HPLC systems. Fused-Core® superficially porous silica particles with pore sizes ranging from 90 to a maximum of 1000 Å provide excellent separation of glycans and very large proteins (such as monoclonal antibodies (mAb)) or proteins with molecular weights greater than 100 kDa.