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Septa, commonly known as septum or stoppers, are essential laboratory components used to seal containers, such as vials, bottles, or chromatography columns. Made from various materials like silicone, PTFE, or rubber, septa create a hermetic seal to prevent the ingress of contaminants or the escape of sample contents. They feature a central puncturable area, which allows for syringe needles or probes to access the sample within the container while maintaining an airtight seal when not in use. Septa are vital in applications like gas chromatography (GC) and liquid chromatography (LC), where precise sample handling and sealing are necessary to ensure accurate and reliable results.