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Hyperuricemia Animal Model (CAT#: STEM-AE-0077-WXH)

Introduction

Clinically, hyperuricemia (HUA) refers to the supersaturated state of urate in the extracellular fluid of the body. The blood urate in patients with hyperuricemia usually exceeds 417 μmol/L, and its mechanism is mainly due to increased uric acid production or decreased renal uric acid excretion. Ultra-high protein diet is an important cause of purine metabolism disorder in the body. Excessive intake of sugar, fat, protein, salt and heavy drinking are closely related to the increased incidence of this disease. 5% to 12% of patients with hyperuricemia will develop gout, which can not only invade the bones and joints of patients, but also easily involve the kidneys and cardiovascular system.




Applications

• Research on the mechanism of hyperuricemia.
• Drug research on prevention and treatment of hyperuricemia.

Procedure

• Drug intervention methods: increase the source of uric acid, inhibit uric acid metabolism and excretion, the main modeling drugs include oxonate potassium, hypoxanthine, adenine, ethambutol, niacin, fructose, yeast, etc. drug co-modeling.
• Gene intervention modeling: Knock out related gene targets, including UOX, URAT1, GLUT9, GLUT12, PDZK1.

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