Unlock Exclusive Discounts & Flash Sales! Click Here to Join the Deals on Every Wednesday!

Identification of crystal forms in drug product by Raman Spectroscopy (CAT#: STEM-ST-0061-WXH)

Introduction

The crystalline form of a drug affects properties such as its solubility, stability, dissolution rate, bioavailability and tabletability, and so understanding the crystalline state is crucial for many of the activities of the pharmaceutical industry.




Principle

Raman Spectroscopy is a non-destructive chemical analysis technique which provides detailed information about chemical structure, phase and polymorphy, crystallinity and molecular interactions.
The principle behind Raman spectroscopy is that the monochromatic radiation is passed through the sample such that the radiation may get reflected, absorbed, or scattered. The scattered photons have a different frequency from the incident photon as the vibration and rotational property vary.

Applications

• Analysis of biocompatibility of a material.
• Analysis of nucleic acids.
• Study of interactions between drugs and cells.
• Photodynamic therapy (PDT).
• Analyzing metabolic accumulations of a substance or compounds.
• Diagnosis of disease.
• Analysis of individual cells.
• Cell sorting applications.
• Analyzing the features of biomolecules.
• Study of bone structure.

Procedure

1. Preparation of samples
2. Determine instrument parameters
3. Perform background scan
4. Test the sample
5. Data analysis

Materials

• Raman Spectrometer
• Raman Imaging Microscope
Advertisement