In Vivo Pharmacodynamic Evaluation of Atherosclerosis Model in ApoE KO Mice (CAT#: STEM-AE-0668-LGZ)

Atherosclerosis (AS) is the main cause of coronary heart disease, cerebral infarction and peripheral vascular disease. Lipid metabolism disorders are the pathological basis of atherosclerosis, which is characterized by the affected artery lesions starting from the intima, usually with accumulation of lipid and complex sugars, bleeding and thrombosis, and then fibrous tissue hyperplasia and calcinosis, and gradual metamorphosis and calcification of the middle artery, resulting in thickening and hardening of the artery wall and narrowing of the vascular cavity. The lesion usually involves the large and medium muscle arteries, and once it develops enough to block the lumen of the artery, the tissue or organ supplied by the artery will become ischemic or necrotic. The accumulation of lipids in the inner lining of the arteries is called atherosclerosis because of their yellowish appearance.

Metabolic Disease

1. Disease model construction.
2. Mice dosing.
3. Efficacy monitoring.
4. Biochemical detection of tissue samples.

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