In Vivo Pharmacodynamic Evaluation of B-p53-KO Rats (CAT#: STEM-AE-0659-LGZ)

Introduction

Tumor suppressor p53 encoded by Tp53 gene contributes to cell cycle arrest, apoptosis, senescence, DNA repair and metabolism. Homozygous Tp53 null rats display onset of spontaneous tumors at 4~6 months of age. B-p53-KO rats is a useful model for studying tumor formation, screening of in vivo carcinogenicity, and examining the efficacy of therapeutic agents.

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Principle Applications Procedure Materials Notes Related Products

Principle

Spontaneous tumor model is an animal model in which mice carry oncogene or tumor suppressor gene mutation by gene editing technology, which can spontaneously form tumor in immune-healthy mice. Compared with the tumor transplantation model, the histopathological and molecular characteristics of the spontaneous tumor tissues in this model are similar to those of human tumor tissues, with genetic heterogeneity and the ability to spontaneously metastasize. It can better simulate the occurrence and development process of human tumor diseases.

Applications

In vivo pharmacodynamic analysis was performed by Humanized Mice.

Procedure

1. Disease model construction.
2. Mice dosing.
3. Efficacy monitoring.
4. Biochemical detection of tissue samples.

Materials

• Sample Type: liquid or powder

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