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In Vivo Pharmacodynamic Evaluation of CAL27 Cell Line Based Oral Cancer (CAT#: STEM-AE-0092-LGZ)

Introduction

Oral cancer is the general term for malignant tumors occurring in the oral cavity. Most of them belong to squamous cell carcinoma, which is called mucosal mutation. In clinical practice, oral cancer includes gingival cancer, tongue cancer, soft and hard palate cancer, maxillary bone cancer, floor of mouth cancer, oropharynx cancer, salivary gland cancer, lip cancer, maxillary sinus cancer and cancer occurring in the skin and mucosa of the face. Oral cancer is one of the most common malignant tumors of head and neck.




Principle

In vivo activity is the gold standard for the evaluation of drug biological activity, and it is the first verification of non-human comprehensive activity. In vivo pharmacodynamic evaluation plays a decisive role in the confirmation of candidate molecules and the screening of clinical target indications, and is an indispensable link in the development of new drugs. We provide a variety of disease animal models including inflammation, immunity, metabolism, etc., to meet the needs of different new drug research and development projects of customers, and accept customized services.
In vivo pharmacodynamic evaluation, as the basic research of new drugs, is carried out on animals. It is to verify the effect of drugs with the comprehensive participation of a number of other factors, and to understand the effect of drugs on a certain part of the body by comparing and analyzing the animal signs, in vitro organs, blood components, histone expression and tissue changes before and after drug administration.

Applications

Oral Cancer

Procedure

1. Disease model construction.
2. Mice dosing.
3. Efficacy monitoring.
4. Biochemical detection of tissue samples.

Materials

• Sample Type: liquid or powder

Notes

Oncology efficacy Service package:
In vivo syngeneic model
In vivo CDX model
In vivo PBMC humanized model
In vivo transgenic mouse model
In vivo orthotropic or Metastasis tumor model
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