In Vivo Pharmacodynamic Evaluation of ConA Induced Acute Liver Injury Model (CAT#: STEM-AE-0665-LGZ)

Introduction

Metabolic diseases are diseases caused by the accumulation or deficiency of certain metabolic substances such as sugars, fats, proteins (amino acids), purines, pyrimidines, and copper when biochemical processes in the body are disrupted. Symptoms vary in severity and diagnosis depends on clinical manifestations and blood, urine and other biochemical tests. There is no effective cure, the main is to eliminate the cause and symptomatic treatment. The prognosis depends on the etiology, severity of symptoms and treatment effect.

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Principle Applications Procedure Materials Notes Related Products

Principle

The pathogenesis and pathological changes in the ConA-induced mouse hepatitis model, in which liver injury is mediated by T cell and macrophage activation, partially mimic those of human autoimmune hepatitis, and therefore this model has been widely used to study the pathogenesis, pathological changes, and clinical treatment of diseases such as autoimmune hepatitis. Hepatocyte apoptosis, necrosis, and leukocyte infiltration are seen as prominent features of immune hepatitis. In this model, activated T cells and macrophages infiltrate the liver tissue mesenchyme and induce the secretion of several pro-inflammatory factors, such as TNF-α, IFN-γ, IL-1β and IL-2.

Applications

Metabolic Disease

Procedure

1. Disease model construction.
2. Mice dosing.
3. Efficacy monitoring.
4. Biochemical detection of tissue samples.

Materials

• Sample Type: liquid or powder

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