IonWorks Quattro Automated Patch Clamp System, Molecular Devices, LLC (CAT#: STEM-LE-0525-LC)

The high throughput and low operating cost of the IonWorks Quattro system make it very suitable for the initial screening of directed libraries, compound spectrum analysis and safety assessment. Automated patch clamp systems provide higher throughput than conventional patch clamps, but there is still an urgent need to match the throughput of alternative assays while reducing the assay cost per compound. To achieve this goal, Molecular Devices has developed the IonWorks® Quattro™ system with population patch clamping (PPC) technology. PPC technology can improve data quality and bring stability and consistency, which is necessary for robust single-point screening and pharmacological analysis of ion channel targets. In the IonWorks Quattro system experiment, the change between wells is so consistent that a highly robust Z'-factor can be obtained, and is similar to the Z'-factor value obtained on the FLIPR® system.

Type:Automated, High throughput

Parallel data acquisition on a 384-well PatchPlate board, using 48 discrete amplifiers combined with 12 or 48-channel pipette heads, can achieve a throughput of more than 2300 data points per day.
Automated experiment runs can collect 384 data points without user intervention.
IonWorks PatchPlate consumables provide direct electrophysiological measurements at the lowest cost per data point.
Population Patch Clamp™ (PPC) (patent pending) is an enabling technology that reduces differences between wells [link to PPC technology page] to provide consistent high-quality results.
Supports single-well (SH) recording to obtain data from individual cells during ion channel assay optimization and clone selection during cell line generation.
Use indicators to quickly analyze ion currents for easy integration into data analysis workflows
A cleaning station with fixed pipette tips eliminates residual compounds

Axon Digidata® 1550 System, Axon Instruments Patch-Clamp Amplifiers, IonFlux Automated Patch Clamp Systems, IonWorks Barracuda system