Monoclonal Antibodies Discovery and Production

Monoclonal antibodies (mAbs) are essential molecules that are widely used for research, diagnostic and therapeutic applications, such as function study of specific proteins, detection of specific markers or proteins associated with certain diseases, targeted therapy for the treatment of cancer, prevention and treatment of viral or bacterial infections, etc.

Microfluidics technology has been increasingly used in the discovery and production of monoclonal antibodies due to its ability to accurately control small volumes of fluids and facilitate optimized mixing and reaction conditions. The integration of microfluidics technology in the discovery and production of monoclonal antibodies has the potential to streamline the process, increase efficiency, and improve the quality of the final product.

What We Can Do for You

STEMart uses microfluidics technology to streamline the screening process of antibody-producing cells for specificity and functional activity and optimize the production of monoclonal antibodies by controlling the culture conditions and ensuring uniform distribution of nutrients and growth factors.

• Rapid sorting of antibody secreting cells (ASCs; plasma cells and plasma blasts) with the combination of microfluidic single-cell encapsulation and fluorescence-activated cell sorting (FACS).
• Sequencing of antibody secreting cells to obtain the antibody genes for recombinant expression and characterization of antibodies
• Sequencing of antibodies
• Screening of target-specific antibodies
• Characterization of antibody binding properties
• Functional screening of secreted antibodies for internalization and intracellular signaling, virus neutralization, optimal agonistic properties, and further biotherapeutics
• Production of monoclonal antibodies

For more information about our monoclonal antibodies discovery and production service, please contact us.