The Nano Differential Scanning Calorimeter is designed for characterizationof the molecular stability of dilute solution biomolecules. Compared to competitive designs, Nano DSC uses fewer samples to obtain data. Solid-state thermoelectric elements are used for precise temperature control, and built-in precision linear actuators can maintain constant or controlled variable pressure in the cell. The optional Nano DSC autosampler realizes automation, unattended continuous operation, and increased sample throughput.