Nikon's high-content microscope system uses the Eclipse Ti inverted microscope in combination with NIS-Elements HC software to provide a dedicated interface for high-content acquisition and analysis programs that is built on an integrated database for seamless data management and processing. The Ti Perfect Focus microscope has interchangeable options for high-speed piezoelectric-based autofocus, plate processing, solid-state light sources and fast wavelength switching, as well as full-scale NIS-Elements camera model support. In addition, the magnification filter and the fluorescence filter are interchangeable, thereby expanding imaging possibilities and experimental analysis design options.