Recombinant Human BMP-4 Protein, Seafrom (CAT#: STEM-CT-0030-ZJF)

The Recombinant Human BMP-4 Protein manufactured by Seafrom is suitable for embryonic development and cell differentiation.
Bone morphogenetic proteins (BMPs) belong to the TGF-β superfamily of structurally related signaling proteins. Members of this superfamily are widely distributed throughout the body and play roles in various physiological processes during both pre- and postnatal life. Similar to BMP-7, BMP-4 is involved in the development and maintenance of bone and cartilage. Reduced expression of BMP-4 is associated with several bone diseases, including the hereditary disorder Fibrodysplasia Ossificans Progressiva.
The lyophilized formulation can be stored at 2-8°C for 24 months. For reconstitution, it can be dissolved in injection-grade water, physiological saline, culture medium, or PBS. After dissolution, it should be divided into smaller aliquots and stored at -20°C for 6 months or at -80°C for 12 months, with a final concentration after dilution not lower than 100μg/mL. Avoid repeated freeze-thaw cycles.

Expression Host: HEK293 Cells
Synonyms: Bone Morphogenetic Protein-4, BMP-2B, DVR4
Protein Sequence: DNA sequence encodes human BMP-4 (NP_001334841.1) with an Fc tag at the C-terminus, predicted molecular weight of 40.1 kD
Purity: >90%, analyzed by SDS-PAGE
Endotoxin Level: <0.1 EU/μg
Biological Activity: Ability to induce alkaline phosphatase production in ATDC-5 cells, ED50 ≤ 50 ng/mL
Purification Method: Chromatographic purification
Appearance: White loose body

Stable Cell Library
Large-Scale Expression
High Activity
Batch Stability
Gmp-Quality Control
Ensured Product Quality

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