Recombinant Human EGFR Protein, Seafrom (CAT#: STEM-CT-0121-ZJF)

The Recombinant Human EGFR Protein manufactured by Seafrom is suitable for cancer therapy and research.
The Epidermal Growth Factor Receptor (EGFR; ErbB-1; HER1) is a cell surface receptor that belongs to the epidermal growth factor receptor family, which is a family of cell surface receptors for extracellular protein ligands of the epidermal growth factor family. The Epidermal Growth Factor Receptor is a member of the ErbB receptor family, which comprises four closely related receptor tyrosine kinases: EGFR (ErbB-1), HER2/c-neu (ErbB-2), Her 3 (ErbB-3), and Her 4 (ErbB-4). Mutations that affect the expression or activity of the Epidermal Growth Factor Receptor can potentially lead to the development of cancer.
Storage Information:
Lyophilized samples can be stored at 4°C for 24 months. After reconstitution, the liquid can be stored at -20°C for 6-12 months, while avoiding repeated freeze-thaw cycles.

Expression Host: Human HEK293 cells
Source: Human
Synonyms: EGFR, ERBB, ERBB1, HER1, PIG61, mENA
Protein Sequence: The DNA sequence encodes human EGFR (UniProtKB - P00533), expressed with a His tag at the C-terminus.
Molecular Weight: Recombinant human EGFR protein contains 620 amino acids, with a predicted theoretical molecular weight of 70.3 kD.
Purity: ≥95%, confirmed by SDS-PAGE gel and high-performance liquid chromatography (HPLC) analysis.
Endotoxin: <0.1 EU/μg
Biological Activity: Immobilization of cetuximab at 5 μg/mL (100 μL/well) can bind to human epidermal growth factor receptor R (His tag) in a linear range of 0.5-15 ng/mL.
Purification Method: Chromatographic purification
Composition: Sterile PBS (pH 7.4) freeze-dried powder containing 6% mannitol.

Optimal Stability
Gmp-Grade Quality
Low Batch-to-Batch Variability
Exceptional Specificity
Robust Bioactivity
Efficient and Reliable Performance

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