Recombinant Human ICOS Protein, Seafrom (CAT#: STEM-CT-0114-ZJF)

The Recombinant Human ICOS Protein manufactured by Seafrom is suitable for T-cell co-stimulation and immune responses.
Inducible T-cell costimulator (ICOS), also known as Activation-inducible lymphocyte immunomediatory molecule (AILIM) and CD278, belongs to the CD28 family of immune costimulatory receptors, which includes CD28, CTLA-4, and PD-1.
ICOS enhances various fundamental T-cell responses to foreign antigens, including cell proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and providing effective support for antibody secretion by B-cells. CD278/ICOS plays a crucial role in preventing the apoptosis of pre-activated T-cells and is also involved in the CD40-mediated class switching of immunoglobulin isotypes.
Storage Information:
Lyophilized samples can be stored at 4°C for 24 months. Once reconstituted, the liquid can be stored at -20°C for 6-12 months, with care taken to avoid repeated freeze-thaw cycles.

Expression Host: Human HEK293 cells
Source: Human
Synonyms: CD278, AILIM, Inducible T-cell costimulator
Protein Sequence: The DNA sequence encodes human ICOS (NCBI Reference Sequence: NP_036224.1), expressed with an Fc tag at the C-terminus.
Molecular Weight: Recombinant human ICOS protein contains 354 amino acids, with a predicted theoretical molecular weight of 40.7 kD.
Purity: ≥95%, confirmed by SDS-PAGE gel and high-performance liquid chromatography (HPLC) analysis.
Endotoxin: <0.1 EU/μg
Biological Activity: The ability to bind to human B7-H2 (His tag) is confirmed at 2 μg/mL (100 μL/well), with a linear range of 0.2-10 ng/mL.
Purification Method: Chromatographic purification
Composition: Sterile PBS (pH 7.4) freeze-dried powder containing 6% mannitol.

Optimal Stability
Gmp-Grade Quality
Low Batch-to-Batch Variability
Exceptional Specificity
Robust Bioactivity
Efficient and Reliable Performance

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