Recombinant Human IFN-α2b Protein, Seafrom (CAT#: STEM-CT-0046-ZJF)

The Recombinant Human IFN-α2b Protein manufactured by Seafrom is suitable for antiviral and immunomodulatory effects.
Human IFN-α2a and -α2b are allelic variants of the same gene. IFN-α2a and -α2b differ in their mature protein sequences by 23 amino acids, which consist of aspartic acid and arginine residues. They are the only IFN-α subtypes in humans that have O-glycosylation sites. Human IFN-α2b can be induced by co-culturing with CpG oligonucleotides or loxoribine in peripheral blood mononuclear cells (PBMCs) and plasma dendritic-like cells. IFN-α subtypes are classified as intermediate to strong inducers of ISGs (Interferon Stimulated Genes) and exhibit potent antiviral activity against influenza A viruses.
Similar to IFN-α1 and IFN-α8 subtypes, human IFN-α2 is expressed early after Sendai virus infection in vitro and may transmit the "start" signal to neighboring cells regardless of the diversity of virus infection (MOI). Recombinant human IFN-α2 is the only clinically approved subtype, and both IFN-α2a and IFN-α2b are used for the treatment of chronic hepatitis B or C, hairy cell leukemia, and other forms of cancer.
The lyophilized product can be stored at 4°C for 24 months, and the reconstituted liquid can be stored at -20°C for 6-12 months, avoiding repeated freeze-thaw cycles.

Expression Host: HEK293 Cells
Synonyms: IFNA2, IFNA2b, alpha-2a interferon, IFNA, IFN-alpha-2, IFN-alphaA, INFA2, interferon alpha2b; interferon alpha A, interferon alpha-2, Interferon alpha-A, interferon, alpha 2
Endotoxin Level: <1 EU/μg
Potency: 1x10^8 IU/mg
Purification Method: Chromatographic purification
Appearance: White loose body
Storage Temperature: 2-8℃
Expiration Date: 24 months

Stable Cell Library
Large-Scale Expression
High Activity
Batch Stability
Gmp-Quality Control
Ensured Product Quality

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