Recombinant Human IL-6 Protein, Seafrom (CAT#: STEM-CT-0018-ZJF)

The Recombinant Human IL-6 Protein manufactured by Seafrom is suitable for pleiotropic functions, including involvement in inflammation and immune response.
Interleukin-6 (IL-6) is produced by fibroblasts, monocytes, macrophages, T lymphocytes, B lymphocytes, epithelial cells, keratinocytes, and various tumor cells. Several factors, including IL-1, TNF-α, PDGF, viral infections, double-stranded RNA, and cAMP, can induce the production of IL-6 in normal cells. IL-6 can stimulate the proliferation, differentiation, and functional enhancement of cells involved in the immune response. The IL-6 receptor (IL-6R) is widely expressed on the surface of activated B cells, resting T cells, NK cells, myeloma cells, liver cells, myeloid leukemia cells, and more. The main functions of IL-6 include promoting B cell proliferation, differentiation, and antibody secretion, as well as exerting diverse effects on liver cells, T cells, neural tissues, and the hematopoietic system. IL-6 also possesses anti-tumor effects and can directly or indirectly enhance the cytotoxic activity of NK cells and CTLs (cytotoxic T lymphocytes).
The lyophilized formulation can be stored at 2-8°C for 24 months. For reconstitution, it can be dissolved in injection-grade water, physiological saline, culture medium, or PBS. After dissolution, it should be divided into smaller aliquots and stored at -20°C for 6 months or at -80°C for 12 months, with a final concentration after dilution not lower than 100 μg/mL. Avoid repeated freeze-thaw cycles.

Expression Host: HEK293 Cells
Synonyms: IL6, Interleukin-6, BSF2, HSF, IFNB2
Protein Sequence: DNA sequence encodes human IL-6 (NP_000591.1: V30-M212) expressed with a His tag at the C-terminus
Molecular Weight: Predicted theoretical molecular weight of 21.6 kD
Purity: >90%, analyzed by SDS-PAGE
Endotoxin Level: <0.1 EU/μg
Biological Activity: Cell proliferation assay using TF-1 cells, activity ≥2.0x10^7 U/mg
Purification Method: Chromatographic purification
Appearance: White loose body

Stable Cell Library
Large-Scale Expression
High Activity
Batch Stability
Gmp-Quality Control
Ensured Product Quality

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