Recombinant Human LAG-3 (Fc) Protein, Seafrom (CAT#: STEM-CT-0161-ZJF)

The Recombinant Human LAG-3 (Fc) Protein manufactured by Seafrom is suitable for immune regulation and checkpoint inhibition.
Lymphocyte activation gene 3 protein (LAG3), also known as CD antigen CD223 and protein FDC, belongs to the immunoglobulin (Ig) superfamily and contains 4 extracellular Ig-like domains. The LAG3 gene comprises 8 exons, and its sequence data, exon/intron organization, and chromosomal localization all indicate a close relationship to CD4. LAG3/CD223 is involved in lymphocyte activation and binds to HLA class-II antigens.
The lyophilized form can be stored at 4℃ for 24 months, and the reconstituted liquid can be stored at -20℃ for 6-12 months, avoiding repeated freeze-thaw cycles.

Expression Host: Human HEK293 cells
Source: Human
Synonyms: CD223, FDC
Protein Sequence: The DNA sequence encodes human LAG3 (NCBI Reference Sequence: NP_001762.2), expressed with an Fc tag at the C-terminus.
Molecular Weight: Recombinant human LAG-3 protein contains 689 amino acids, with a predicted theoretical molecular weight of 75.6 kD.
Purity: ≥95%, confirmed by SDS-PAGE gel and high-performance liquid chromatography (HPLC) analysis.
Endotoxin: <0.1 EU/μg
Biological Activity: Immobilized anti-LAG-3 (Fc tag) antibody at 5 μg/mL (100 μL/well) can bind to human FGL-1 (His tag) in a linear range of 50-200 ng/mL.
Purification Method: Chromatographic purification
Composition: Sterile PBS (pH 7.4) freeze-dried powder containing 6% mannitol.

Optimal Stability
Gmp-Grade Quality
Low Batch-to-Batch Variability
Exceptional Specificity
Robust Bioactivity
Efficient and Reliable Performance

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