Recombinant Human MUC-1 Protein, Seafrom (CAT#: STEM-CT-0111-ZJF)

The Recombinant Human MUC-1 Protein manufactured by Seafrom is suitable for cancer biology and immunotherapy.
Mucin 1, cell surface associated (MUC1), also known as polymorphic epithelial mucin (PEM), is a membrane-bound protein belonging to the mucin family. Mucins are O-glycosylated proteins that play a crucial role in the formation of protective mucous barriers on epithelial surfaces. Additionally, these proteins are involved in intracellular signaling.
MUC1 is expressed on the apical surface of epithelial cells that line the mucosal surfaces of various tissues, including the lung, breast, stomach, and pancreas. It is exclusively located in the apical domain of the plasma membrane of highly polarized epithelial cells. After endocytosis, it is internalized and recycled to the cell membrane.
MUC1 is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell adhesion, while the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. The alpha subunit possesses cell adhesive properties and can act both as an adhesion and anti-adhesion protein. It may provide a protective layer on epithelial cells against bacterial and enzyme attacks.
Storage Information:
Lyophilized samples can be stored at 4°C for 24 months. Once reconstituted, the liquid can be stored at -20°C for 6-12 months, with care taken to avoid repeated freeze-thaw cycles.

Expression Host: Human HEK293 cells
Source: Human
Synonyms: Mucin 1, MUC1, CD227, EMA, H23AG, KL-6, MAM6, MUC-1/SEC, MUC-1/X, MUC1/ZD, PEM, PEMT, PUM, CA15-3, Episialin
Protein Sequence: The DNA sequence encodes human MUC-1 (UniProtKB/Swiss-Prot: P15941), expressed with an Fc tag at the C-terminus.
Molecular Weight: Recombinant human MUC-1 protein contains 366 amino acids, with a predicted theoretical molecular weight of 38.4 kD.
Purity: ≥95%, confirmed by SDS-PAGE gel and high-performance liquid chromatography (HPLC) analysis.
Endotoxin: <0.1 EU/μg
Purification Method: Chromatographic purification
Composition: Sterile PBS (pH 7.4) freeze-dried powder containing 6% mannitol.

Optimal Stability
Gmp-Grade Quality
Low Batch-to-Batch Variability
Exceptional Specificity
Robust Bioactivity
Efficient and Reliable Performance

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