Recombinant Human PD-L2 Protein, Seafrom (CAT#: STEM-CT-0144-ZJF)

The Recombinant Human PD-L2 Protein manufactured by Seafrom is suitable for immune checkpoint regulation.
Programmed cell death 1 ligand 2 (PD-L2 or PDCD1 ligand 2) is a protein also known as Butyrophilin B7-DC and CD273. It belongs to the immunoglobulin superfamily or BTN/MOG family. The expression of PD-L2 is up-regulated by IFNG/IFN-gamma stimulation in monocytes and induced on dendritic cells grown from peripheral blood mononuclear cells with CSF2 and IL-4.
PD-L2 is involved in the costimulatory signal, which is essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. The interaction of PD-L2 with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production.
For storage, lyophilized (freeze-dried) products can be stored at 4°C for 24 months. After reconstitution, the liquid can be stored at -20°C for 6-12 months, and it is recommended to avoid repeated freeze-thaw cycles.

Expression Host: Human HEK293 cells
Source: Human
Synonyms: PDL2, Butyrophilin B7-DC, CD273, PDCD1 ligand 2, PDCD1L2, PDCD1LG2
Protein Sequence: The DNA sequence encodes human PD-L2 (NCBI Reference Sequence: NP_079515.2), expressed with a His tag at the C-terminus.
Molecular Weight: Recombinant human PD-L2 protein contains 201 amino acids, with a predicted theoretical molecular weight of 24 kD.
Purity: ≥95%, confirmed by SDS-PAGE gel and high-performance liquid chromatography (HPLC) analysis.
Endotoxin: <0.1 EU/μg
Biological Activity: Immobilized human PD-L2 (His tag) at a concentration of 10 μg/mL (100 μL/well) can bind to human PD-1 (FC tag) in a linear range of 0.01-1 μg/mL.
Purification Method: Chromatographic purification
Composition: Sterile PBS (pH 7.4) freeze-dried powder containing 6% mannitol.

Optimal Stability
Gmp-Grade Quality
Low Batch-to-Batch Variability
Exceptional Specificity
Robust Bioactivity
Efficient and Reliable Performance

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