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SSCP analysis is a widely used screening method for identifying genomic variants in a large number of samples and in a broad range of organisms, from microorganisms to humans. SSCP analysis detects sequence variations (single-point mutations and other small-scale changes) through electrophoretic mobility differences. When subjected to nondenaturing (or partially denaturing) electrophoresis, DNA that contains a sequence mutation (even a single base pair change) and the wild-type sequence have measurable mobility differences.
DNA fragment analysis enables a multitude of applications from genotyping to bacteria identification and from plant screening to gene expression profiling.