Structural analysis of Monoclonal Antibody by Circular dichroism (CD) (CAT#: STEM-MB-0631-WXH)

Introduction

Monoclonal antibodies are laboratory-produced molecules engineered to serve as substitute antibodies that can restore, enhance, modify or mimic the immune system's attack on cells that aren't wanted, such as cancer cells. Briefly, mAbs are comprised of four polypeptide chains, two identical heavy chains and two identical light chains, with a total molecular weight of ~150kD. The chains are held together by disulfide linkages and fold to form a “Y” shaped tetramer