Study of metal allergenic substances on the skin (CAT#: STEM-ST-0290-LJX)

Introduction

By spark source mass spectrography it is possible to trace very low concentrations of substances such as chromium, cobalt, and nickel in ethanol extracts of the skin. Chromium could be detected in abnormally high concentrations 3 weeks after one application, while nickel and cobalt reached background levels after 2 to 3 weeks. Touching a door handle containing chromium leads to a significant rise in the chromium content of the skin. Increased chromium content of the skin was evident in one case of wristwatch eczema as well.

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Principle Applications Procedure Materials Notes Related Products

Principle

By using vacuum spark discharge, the energy accumulated in a small volume can make the material in the volume suddenly evaporate and ionize, so as to obtain the characteristic ion current information.

Applications

(1) Solid spark source mass spectrometry: impurity analysis of high-purity materials, which can be applied to semiconductor materials, non-ferrous metals, and building materials industries;
(2) Gas isotope mass spectrometry: determination of stable isotopes C, H, N, O, S and radioactive isotopes Rb, Sr, U, Pb, K, Ar, which can be applied to geology, petroleum, medicine, environmental protection and agriculture.

Procedure

(1) An electric field is applied between the electrodes to ionize part of the carrier gas (such as argon) in the electric field;
(2) The "cathode ray" or "anode ray" generated by ionization accelerates in the direction of the opposite polarity in the residual gas, bombards the anode or cathode, and vaporizes a part of the substance to be measured on the plate;
(3) Part of the atoms of the vaporized substance are ionized in the subsequent discharge process.

Materials

• Sample Type:
Skin

Notes

Before starting the machine, check whether the water (water cooler), electricity, gas (argon/nitrogen), temperature, humidity, and exhaust air of the instrument are normal.

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