Study on the Interactions of Chlorpromazine Hydrochloride and Promethazine Hydrochloride with Nucleic Acids by Resonance Rayleigh Scattering Spectrum (CAT#: STEM-ST-0036-YJL)

Introduction

The interaction between nucleic acids and medicine molecule is one of the important research fields of nucleic acids, which is very valuable for investigating the interactive mechanisms of anti-cancer and anti-virus medicine, screening medicine in vitro, diagnosing and treating some diseases, and designing and synthesizing new medicine. Many anti-cancer medicines, widely used in clinics, take DNA as primary target and damage its structure through interacting with DNA of cancer cell, then influence the ability of gene adjustment and expression, and show its anti-cancer activity.
The basic structures of chlorpromazine hydrochloride [CPZ, 2-chloro-10-(3-dimethylaminopropyl) phenothiazine hydrochloride], and promethazine hydrochloride [PZ, 10-(2-dimethylaminopropyl) phenothi-azine hydrochloride] are similar. The only difference between CPZ and PZ is the different propyl group, which links up with –N(CH3)2 and the nitrogen atom of phenothiazine (the former is n-propyl, the latter is isopropyl).