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Acute pancreatitis (AP) is one of the common acute abdominal diseases in clinical practice. A variety of causes lead to the activation of pancreatic enzymes in the pancreas, leading to an inflammatory reaction of pancreatic tissue self-digestion, edema, hemorrhage and even necrosis. It has the characteristics of acute onset, rapid development, many complications, and high mortality rate. An ideal AP animal model is of great significance for the study of its pathogenesis and treatment measures. The methods used to establish the model include drug injection induction, food induction and ligation.