Non-alcoholic Fatty Liver Animal model (CAT#: STEM-AE-0066-WXH)

Introduction

Nonalcoholic fatty liver disease is considered a hepatic manifestation of the metabolic syndrome, which is on the rise worldwide, along with obesity, hyperlipidemia, and type 2 diabetes. Nonalcoholic fatty liver disease includes a wide range of liver abnormalities, ranging from simple steatosis to nonalcoholic fatty liver inflammation (NASH).

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Principle Applications Procedure Materials Notes Related Products

Applications

• Elucidating the pathogenesis of nonalcoholic fatty liver disease.
• Testing the therapeutic effect of various drugs.

Procedure

One of the most widely used models of NASH is feeding animals a methionine-choline-deficient (MCD) diet containing high sucrose and high fat (40% sucrose, 10% fat) but deficient in methionine and choline, which leads to liver β-oxidation and very low-density lipoprotein (VLDL) production. The main outcome of feeding the MCD diet was a reduction in hepatocyte lipid accumulation and VLDL synthesis.

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