Adhesion forces measured between a calcium blocker drug and its receptor in living cells by atomic force microscope (CAT#: STEM-SMMT-0029-LJX)

Introduction

Nimodipine is a calcium blocker, belonging to the dihydropyridine class, used for the improvement of blood circulation in the convalescent period of acute cerebrovascular disease, cerebrovascular spasm after various causes of subarachnoid hemorrhage, and ischemic neurological disorders caused by hypertension, migraine, etc. It has also been used as a treatment for ischemic neuronal protection and vascular dementia, and has shown some efficacy in sudden deafness. It is often used in the clinical medicine of hypertension.
Saccharomyces cerevisiae is the most widely related to human yeast, which is often used in the production of bread, steamed bread and other food and wine making.
The adhesion force between the tip of an atomic force microscope cantilever derivatized with nimodipine (a calcium blocker, from the dihydropyridine class, currently used in clinical medicine for hypertension) and living cells of Saccharomyces cerevisiae (unicellular eukaryotes which portray ultrastructural features characteristic of higher eukaryotic cells) was measured in this service.