Analysis Affinity of Protein to Recombinant Cynomolgus P-cadherin (human,monkey) by KinExA (CAT#: STEM-MB-0043-CJ)

Introduction

Classical cadherins (E-, N-, and P-cadherin) comprise a family of molecules that mediate calcium-dependent cell-cell adhesion and are localized at the adherens junctions. P-cadherin overexpression has correlate with increased tumor cell motility and invasiveness. Upregulation of P-cadherin has been reported in various tumors, including breast, gastric, endometrial, colorectal and pancreatic cancers, and is correlated with poor survival of breast cancer patients. In contrast, low levels of the P-cadherin gene expression have been detected in normal tissues. P-cadherin therefore represents an interesting target for the treatment of solid tumors that show increased levels of expression.Bispecific antibodies (bsAb) have emerged in recent years as promising agents for immune-mediated tumor cell killing. The approval by the US E64of the bispecific T cell engager blinatumomab for the treatment of relapsed or refractory B cell precursor acute lymphoblastic leukemia.