Analysis Biomolecular Interactions of DNA Aptamers with Marine Biotoxin Gymnodimine-A by BLI (CAT#: STEM-MB-0104-CJ)

Introduction

Gymnodimines (GYMs) are the smallest members of cyclic imines (CIs) in terms of molecular weight. They are characterized as fast-acting toxins, which can accumulate in filter feeding shellfish and may pose a potential risk to human health and the aquaculture industry. Being first discovered in New Zealand oysters, GYMs have been detected in pipis (Donax deltoides), mussels (Modiolus proclivis), oysters (Saccostrea glomerata), and seawater in many countries. GYMs can also be isolated from the dinoflagellates Alexandrium ostenfeldii (Alexandrium peruvianum ) and Karenia selliformis, which are harmful algal bloom species. The stereochemical structure of gymnodimine-A (GYM-A) was first elucidated by nuclear magnetic resonance (NMR) in 1995. It respective molecular weight is around 520. As liposoluble toxins, the typical chemical structure of GYMs contains a macrocycle ring, a spirocyclic imine ring, and an ether moiety.